Use of cultured epithelial cells, including keratinocytes, for the detection of antinuclear antibodies.
Open Access
- 1 December 1987
- journal article
- research article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 46 (12) , 929-933
- https://doi.org/10.1136/ard.46.12.929
Abstract
The use of cultured human epithelial cells as a substrate for the detection of antinuclear antibodies (ANAs) improves the sensitivity of detection above the standard substrates used. Standard antisera have been screened against a series of epithelial cell lines, including keratinocytes. Selected cells have then been used to detect ANAs in 78 patients with discoid lupus erythematosus.Keywords
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