Ocular Manifestations of Whipple Disease
- 1 September 1998
- journal article
- case report
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 116 (9) , 1232-1234
- https://doi.org/10.1001/archopht.116.9.1232
Abstract
A 62-year-old man developed bilateral granulomatous iridocyclitis after uncomplicated cataract surgery. On ophthalmic examination, we found moderate inflammation in the anterior chamber and vitreous, with granular crystalline deposits on the iris, intraocular lens, and capsular bag. Biopsy of the lens capsule and vitreous revealed periodic acid–Schiff–positive, diastase-resistant bacilli consistent with Tropheryma whippelii. Electron microscopy and polymerase chain reaction confirmed the diagnosis of Whipple disease. A jejunal biopsy specimen also revealed T whippelii. Treatment with trimethoprim-sulfamethoxazole, cefixime, rifampin, and doxycycline resulted in improvement of systemic symptoms, but intraocular inflammation persisted. Intraocular inflammation was eventually reduced with the intravenous administration of ceftriaxone sodium.Keywords
This publication has 1 reference indexed in Scilit:
- Intraocular penetration of rifampin after oral administrationAlbrecht von Graefes Archiv für Ophthalmologie, 1990