Inhibition of Adherence and Phagocytosis of Zymosan Particles by Mouse Peritoneal Macrophages with Hydrocortisone

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Abstract
The relationships between adherence of zymosan and pagocytosis by macrophages with the release of 6-keto-prostaglandin F1.alpha. (6KF1.alpha.) and thromboxane B2 (TXB2), the stable endeometabolites PGI2 and TXA2, respectively, from macrophages were investigated with mouse peritoneal macrophages. Zymosan-induced release of 6KF1.alpha. and TXB2 was inhibited by indomethacin, an inhibitor of cyclo-oxygenase, and by hydrocortisone, an inducer of the inhibitor of phospholipase A2. Although release of 6KF1.alpha. and TXB2 was significantly enhanced by the interaction of attachment of zymosan particles to cell membranes, the interaction was inhibited by hydrocortisone, not by indomethacin. Evidently, phospholipase A2 participates in the interaction of zymosan particles with cell membranes for the release of 6KF1.alpha. and TXB2.

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