Multi-tracer small animal PET imaging of the tumour response to the novel pan-Erb-B inhibitor CI-1033
- 1 February 2006
- journal article
- Published by Springer Nature in European Journal of Nuclear Medicine and Molecular Imaging
- Vol. 33 (4) , 441-452
- https://doi.org/10.1007/s00259-005-0039-5
Abstract
This study was designed as “proof of concept” for a drug development model utilising multi-tracer serial small animal PET imaging to characterise tumour responses to molecularly targeted therapy.Keywords
This publication has 61 references indexed in Scilit:
- TYROSINE KINASE INHIBITORS AND THE DAWN OF MOLECULAR CANCER THERAPEUTICSAnnual Review of Pharmacology and Toxicology, 2005
- Modulation of intratumoral hypoxia by the epidermal growth factor receptor inhibitor gefitinib detected using small animal PET imagingMolecular Cancer Therapeutics, 2005
- ERBB receptors and cancer: the complexity of targeted inhibitorsNature Reviews Cancer, 2005
- Targeted cancer therapyNature, 2004
- Metabolism of 3′-deoxy-3′-[F-18]fluorothymidine in proliferating A549 cells: Validations for positron emission tomographyNuclear Medicine and Biology, 2004
- Brca1 inactivation induces p27Kip1-dependent cell cycle arrest and delayed development in the mouse mammary glandOncogene, 2004
- Value of FDG PET Imaging in the Management of Patients With Thyroid, Neuroendocrine, and Neural Crest TumorsClinical Nuclear Medicine, 2004
- Design evaluation of A-PET: A high sensitivity animal PET cameraIEEE Transactions on Nuclear Science, 2003
- [18F]Fluoroazomycinarabinofuranoside (18FAZA) and [18F]Fluoromisonidazole (18FMISO): a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumorsNuclear Medicine and Biology, 2003
- Nitroimidazoles and imaging hypoxiaEuropean Journal of Nuclear Medicine and Molecular Imaging, 1995