Abstract
In 1975, 229 laboratory-documented cases of St Louis encephalitis, 36 of which resulted in death, occurred in Mississippi, USA. A total of 58% of these persons had encephalitis, 15% had aseptic meningitis, 21% had a febrile illness with no known CNS involvement and 6% had other syndromes. Attack rates and case-fatality ratios increased with age. Although 60% of the cases occurred in a 4-county area of NW Mississippi, cases occurred in 42 of the 82 counties throughout the state. The epidemic erupted almost simultaneously, with variable intensity, in widely separated areas. Mosquito control measures were applied, but the results were not quantified.

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