A reinterpretation of the nature of "lipovirus" cytopathogenicity.

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Abstract
The morphologic events in tissue-cultured cells which have been used to identify and to show the transmission of "lipovirus" have not been found to occur only in the presence of intact amoeboid cells. No evidence has been found to support the earlier interpretations that the causative agent of these events is viral in nature. The amoeboid cells are capable of growth in, destruction of, and eventual overgrowth of cocultured animal cells, displaying the phenomena which were thought to result from a "cytopathic" agent. The amoeboid cell is similar to the small, free-living Hartmannellid amoebae. Spongiform bodies are present as normal structures in these amoebae.