Stability indicating assay for dipyrone. Part II. Separation and quantitative determination of dipyrone and its degradation products by high-performance liquid chromatography
- 1 January 1982
- journal article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 107 (1270) , 67-70
- https://doi.org/10.1039/an9820700067
Abstract
A rapid, sensitive and reproducible procedure for separation and quantification of dipyrone and three of the degradation products is proposed, using high-performance liquid chromatography on a reversed-phase column and ultraviolet detection. The method is about ten times more sensitive (detection limit 3–5 ng) than thin-layer chromatography and requires only a 12-min elution time. This method has been applied to the analysis of tablets and injections.Keywords
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