Partial hepatectomy and mediators of inflammation decrease the expression of liver α2‐HS glycoprotein gene in rats
Open Access
- 29 October 1990
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 273 (1-2) , 79-81
- https://doi.org/10.1016/0014-5793(90)81055-s
Abstract
Liver mRNA levels of two acute phase reactant (APR) proteins, α2‐HS glycoprotein (a major negative APR) and α1,‐acid glycoprotein (a major positive APR) were measured in male rats at different times after the administration of turpentine, of tumor necrosis factor, or following partial hepatectomy. In every case, a marked decrease in mRNA levels of α2HS glycoprotein was observed which reached a maximum at 24 h. A concomitant increase of α1,‐acid glycoprotein mRNA levels was observed under the same conditions. These results indicate that the decreased levels of α2‐HS glycoprotein induced by the acute‐phase response following inflammatory mediators and partial hepatectomy are due to a down‐regulation of the gene expression of this protein in rat liver.Keywords
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