Serum Lipids and Lipoproteins in Type 2 Diabetic Patients with Persistent Microalbuminuria

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Abstract
To investigate whether persistent microalbuminuria is related to altered levels of both lipids and apolipoproteins in Type 2 diabetes mellitus serum total‐cholesterol, triglycerides, HDL‐cholesterol, LDL‐cholesterol, apolipoprotein A‐l, and apolipoprotein B were measured by standard methods in a group of Type 2 diabetic patients affected by persistent microalbuminuria (albumin excretion rate (AER) 20–200 μg min−1) as compared with a group of sex‐ and age‐matched non‐microalbuminuric patients (AER < 20 μg min−1). The groups were stratified according to a short (< 5 years) or a longer (> 5 years) duration of diagnosed diabetes. Microalbuminuria was not associated with significant changes of serum total‐cholesterol, triglycerides, HDL‐cholesterol, LDL‐cholesterol, and apolipoproteins in the group of patients with a duration of disease > 5 years, while microalbuminuric patients > 5 years from diagnosis (n = 11) had serum total‐cholesterol, triglycerides, LDL‐cholesterol, and apoprotein B higher than non‐microalbuminuric control patients (n = 26) (cholesterol 6.2 ± 0.9 vs 5.1 ±1.0 mmol I−1 (p = 0.003); triglycerides 2.1 ± 0.7 vs 1.7 ± 1.3 mmol I−1 (p = 0.03); LDL‐cholesterol 4.1 ± 0.8 vs 3.0 ± 0.7 mmol I−1 (p< .001); apo‐B 1.3 ± 0.3 vs 1.1 ± 0.3 g I−1 (p = 0.02). In these patients with shorter duration of diabetes many of the serum lipid measures correlated positively with AER.