A RADIOSYNTHESIS OF F-18 FLUOROMISONIDAZOLE

  • 1 March 1989
    • journal article
    • research article
    • Vol. 30  (3) , 343-350
Abstract
A new preparation of [18F]fluoromisonidazole [1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole] is presented as a two-step, two-pot reaction sequence. The method is useful for the production of 20-30 mCi quantities of this compound from [18F]fluoride, available in 40% radiochemical yield at end of bombardment (EOB) with a specific activity (nca) of > 650 Ci/mmol (EOB) and a synthesis time of .apprx. 140 min. The key feature of the reaction scheme is the preparation of a new fluoroalkylating agent, [18F]epifluorohydrin.

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