Time Course of Change in Adenine Nucleotide Content of Rabbit Muscle Following Acute Cold Injury

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Abstract
Rabbit legs were subjected to acute injury for 30 minutes at a temperature of -15[degree]C. The tibialis anticus and extensor digitorum longus, removed at time intervals ranging between 12 and 128 minutes after exposure, decreased in adenosine triphosphate concentration. The maximal effect, previously observed at the end of 18 hours, was already apparent 2 hours after exposure. Dry weight of the tissue decreased. Total purine decreased after a slight lag. Possible explanations of the sequence are discussed. Therapy, if it is to be employed, must be carried out almost immediately after exposure, since the changes described occur very rapidly.