Physiological calcium ion concentration and a cholinergic drug on activity of particulate guanylate cyclase in guinea pig taenia caecum.
- 1 January 1981
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics
- Vol. 4 (9) , 738-741
- https://doi.org/10.1248/bpb1978.4.738
Abstract
The microsomal fraction derived from the tenia cecum of guinea pigs was used as a particulate guanylate cyclase preparation. The guanylate cyclase activity was not influenced by butyltrimethylammonium bromide and Ca2+ (4.0-24 .times. 10-7 M). The particulate guanylate cyclase is apparently not activated by the drug-receptor interaction and also by the increase of intracellular Ca2+ concentration. The increase of tissue level of cGMP brought about in the guinea pig tenia cecum might be due to activation of soluble guanylate cyclase following the increase in the intracellular Ca2+ concentration.This publication has 0 references indexed in Scilit: