Vasopressin Modulates Membrane Properties of Taste Cells Isolated from Bullfrogs
Open Access
- 1 December 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemical Senses
- Vol. 21 (6) , 739-745
- https://doi.org/10.1093/chemse/21.6.739
Abstract
The effect of arginine vasopressin (AVP) on the membrane properties was analyzed in isolated bullfrog taste cells using a perforated whole-cell patch-clamp technique. AVP (100 nM) induced three kinds of responses in rod-type taste cells: appearance of inward current, inhibition of voltage ramp-induced outward current and enhancement of the outward current. The Ca2+-ionophore ionomycin (3 μM) also induced inward current in taste cells. A membrane-permeable cAMP analog, 8-CPT-cAMP (0.3 mM) inhibited voltage ramp-induced outward current in some rod cells, but enhanced the current in other rod cells. The results suggest that AVP may increase either intracellular Ca2+ level or cAMP level in taste cells, modulating the membrane excitability. Chem. Senses 21: 739–745, 1996.Keywords
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