HLA‐DQA1, ‐DQB1 and ‐DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR‐RFLP method
- 1 October 1994
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 44 (4) , 248-251
- https://doi.org/10.1111/j.1399-0039.1994.tb02390.x
Abstract
We performed HLA-DQA1, -DQB1 and -DRB1 genotyping using the PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method for 32 Japanese pemphigus vulgaris (PV) patients. There was a significant association of either DQB1*0503 or DRB1*1405 with PV, and a negative association of either DQA1*0103 or DQB1*0601 with PV was found. Since the DQB1*0503+ patients had various DR14-related alleles, we concluded that the association with DQB1 is primary and that the association with DRB1 is simply due to linkage disequilibrium between the DQ and DR genes. These results may indicate that specific HLA class II antigens confer the susceptibility to PV among Japanese.Keywords
This publication has 18 references indexed in Scilit:
- Identification of a new HLA‐DPB1 allele detected by PCR‐RFLP and its nucleotide sequence determination by direct sequencing after PCR amplificationTissue Antigens, 1993
- Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic.Journal of Clinical Investigation, 1992
- Association of HLA‐B51 and lack of association of class II alleles with Behcet's diseaseTissue Antigens, 1992
- HLA‐DRB1 genotyping by modified PCR‐RFLP method combined with group‐specific primersTissue Antigens, 1992
- New DQwl diversity identified within DRwl2 and DRwl4 haplotypesTissue Antigens, 1991
- HLA class II antigens are associated with Japanese pemphigus patientsHuman Immunology, 1991
- Detection of Pemphigus Vulgaris and Pemphigus Foliaceus Antigens by Immunoblot Analysis Using Different Antigen SourcesJournal of Investigative Dermatology, 1990
- Pemphigus and pemphigoid as paradigms of organ-specific, autoantibody-mediated diseases.Journal of Clinical Investigation, 1989
- HLA‐DR Antigens in Pemphigus among JapaneseTissue Antigens, 1981
- Absence of HLA-DRW2 in Japanese Pemphigus VulgarisJournal of Investigative Dermatology, 1981