Genes for? 2-adrenergic receptor and platelet-derived growth factor receptor map to mouse chromosome 18
- 1 July 1989
- journal article
- conference paper
- Published by Springer Nature in Somatic Cell and Molecular Genetics
- Vol. 15 (4) , 367-371
- https://doi.org/10.1007/bf01534975
Abstract
The β2-adrenergic receptor (ADRB2R) mediates the response of various cell types to neurotransmitters, hormones, and drugs. The platelet-derived growth factor (PDGF) interacts with its receptor (PDGFR) to stimulate mesenchymal cell proliferation. In the human, ADRB2Rand PDGFRhave been mapped to the q31→q32 region of chromosome 5 (HSA5). Here we report the mapping of Pdgfrand Adrb2rto mouse chromosome 18 (MMU18) using somatic cell hybrid mapping techniques. Together with previous mapping of genes for the glucocorticoid receptor (human locus GRL; mouse locus Gr1-1),the class II HLA invariant chain (human locus PHLAG;mouse locus Ii)and the FMSprotooncogene to HSA5 and MMU18, the assignment of both Pdgfr and Adrb2r to MMU18 expands the conserved autosomal syntenic group.This publication has 33 references indexed in Scilit:
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