The distribution of dermal tumorigens in coal liquids: Relationship of tumorigenicity and microbial mutagenicity
- 1 June 1984
- journal article
- research article
- Published by Wiley in Journal of Applied Toxicology
- Vol. 4 (3) , 117-123
- https://doi.org/10.1002/jat.2550040302
Abstract
Polycyclic aromatic hydrocarbons and/or their pyrolle derivatives were found to be the primary contributors to the skin tumorigenicity of the neutral fractions of two coal oils. Mutagenicity of the neutral fraction in Salmonella test strains was found to be due primarily to polycyclic aromatics containing polar substituents. Thus, the chemical classes responsible for skin tumorigencity differ from those responsible for mutagenicity.Keywords
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