Cycasin: Detection of Associated Mutagenic Activity in vivo
- 14 February 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 163 (3868) , 689-691
- https://doi.org/10.1126/science.163.3868.689
Abstract
Cycasin and its lagycone, methylazoxymethanol, increase the mutant frequency of Salmonella typhimurium histidine auxotrophs when tested in the hostmediated assay. As expected, the degree of cycasin-related mutagenic activity depends on the facility with which the compound can be enzymatically deglucosylated by the normal intestinal flora.Keywords
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