Effects of Childhood Leukemia and Chemotherapy on Puberty and Reproductive Function in Girls
- 20 May 1976
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 294 (21) , 1143-1146
- https://doi.org/10.1056/nejm197605202942102
Abstract
Longer survival in childhood leukemia prompted this study of pubertal development and reproductive function in 35 girls and women. Twenty-eight patients (80 per cent) had normal pubertal progression during a median of 74 months after diagnosis of leukemia and 49 months of chemotherapy. Seven patients were abnormal: four exhibited hypothalamic-pituitary dysfunction with suppression of circulating serum gonadotropins (20 mIU per milliliter).This publication has 18 references indexed in Scilit:
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