THE INCREASED SENSITIVITY OF ARTERIAL MUSCLE IN THE PREHYPERTENSIVE PHASE OF EXPERIMENTAL RENAL HYPERTENSION

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Abstract
Renal hypertensive rabbits were markedly more sensitive to the pressor action of pitressin than they had been before partial constriction of the renal arteries. Similar control operations gave negative results. The hypersensitivity to pitressin was a phenomenon of the prehypertensive or early hypertensive phase. The hypertensive animals also gave an abnormal pressor response to noise and fright. Although the latter stimuli operated through the nervous system, the hypersensitivity to a muscle stimulant, pitressin, showed that renal hypertension is characterized by a generalized increase in the reactivity of the muscular coat of the arteries and that this in turn may play an essential role in the production of hypertension.

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