In vitro Assay for Human Breast Cancer Hormone Responsiveness

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Abstract
Primary or metastatic breast carcinoma from 25 patients was studied in vitro for the effect of Cortisol, estradiol, progesterone, and testosterone on uptake of 3H-labeled thymidine into tumor cells. In 23 of these cases an objective clinical response of the tumors to endocrine therapy correlated with the in vitro result. All eight patients whose tumors did not respond in vitro did not respond clinically to endocrine manipulation. Of the 15 patients whose tumors were affected in vitro, 9 had a significant clinical response lasting at least 6 months. The assay appears to select hormonal sensitive tumors from those not affected by any hormonal agent. The specific hormonal responsiveness in vitro correlated with the clinical response to ablative endocrine surgery, tumor exacerbation, or response to exogenous steroid hormones in many but not all tumors.

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