Increased Hepatic Peroxisome Proliferator-Activated Receptor- Coactivator-1 Gene Expression in a Rat Model of Intrauterine Growth Retardation and Subsequent Insulin Resistance

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Abstract
Pase, but not glucokinase. We found that IUGR hepatic PGC-1 protein levels were increased to 230 32% and 310 47% of control values at d 0 and d 21 of life, respectively. Similarly, IUGR hepatic PGC-1 mRNA levels were significantly elevated at both ages. Concurrent with the increased PGC-1 gene expres- sion, IUGR hepatic mRNA levels of G-6-Pase, PEPCK, and FB- Pase were also significantly increased, whereas glucokinase mRNA levels were significantly decreased. These data suggest that increased PGC-1 expression and subsequent hepatic glu- cose production contribute to the insulin resistance observed in the IUGR juvenile rat. (Endocrinology 143: 2486-2490, 2002)

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