Structure elucidation of phomopsin A, a novel cyclic hexapeptide mycotoxin produced by Phomopsis leptostromiformis
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 21,p. 1259-1262
- https://doi.org/10.1039/c39830001259
Abstract
Phomopsin A, the main mycotoxin isolated from cultures of Phomopsis leptostromiformis and the cause of lupinosis disease in animals grazing infected lupins, is a cyclic hexapeptide containing 3-hydroxyisoleucine, 3,4-didehydrovaline, N-methyl-3-(3-chloro-4,5-dihydroxyphenyl)-3-hydroxyalanine, E-2,3-didehydroaspartic acid, E-2,3-didehydroisoleucine, and 3,4-didehydroproline; its 13C n.m.r. spectrum was completely assigned and the amino-acid sequence established unambiguously by extensive heteronuclear 13C-{1H} selective population inversion n.m.r. experiments.Keywords
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