PREVENTION OF SKIN FLAP NECROSIS BY A COURSE OF TREATMENT WITH VASODILATOR DRUGS
- 1 May 1978
- journal article
- research article
- Published by Wolters Kluwer Health in Plastic and Reconstructive Surgery
- Vol. 61 (5) , 738-743
- https://doi.org/10.1097/00006534-197805000-00013
Abstract
Large island skin flaps, comprising the entire abdominal covering in rats, were raised on one neurovascular pedicle in the groin. A standard area of necrosis was produced on the other side from the pedicle. However, when the animals were treated with certain vasodilator drugs for 15 days before and 7 days after the flaps were raised, there was little or no necrosis. The effect of the drug therapy was the same as a surgical delay.Keywords
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