Disappearance of Exogenous Erythropoietin (ESF) from the Blood of Germfree Mice

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Abstract
Summary A slower rate of disappearance of exogenous ESF from the plasma occurs in germfree mice as compared to normal mice. Higher plasma levels of ESF are maintained in X-irradiated than in non-irradiated mice. Possible mechanisms for these findings include a reduced ability of the liver to destroy ESF in the germfree animal and a decreased capacity of the blood-forming organs in the irradiated mouse to utilize the ESF.