Laboratory and clinical studies with sulfametopyrazine as a treatment for bacteriuria in pregnancy
- 1 June 1975
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 1 (2) , 171-186
- https://doi.org/10.1093/jac/1.2.171
Abstract
The ultra long-acting sulphonamide sulfametopyrazine was used as treatment for bacteriuria in pregnancy. In an initial trial a single dose of 2 g was given producing a cure-rate of 68%. In a randomized comparative trial this dose (cure-rate 67%) was compared with conventional treatment with sulphadimidine (cure-rate 50%, and with 2 similar doses given at an interval of 4 days (cure-rate 73%, The volunteer pharmacological studies which lead to development of this last dosage regime are described, as is the effect of urinary alkalization on pharmacology. Side effects with sulfametopyrazine occurred only infrequently and were considerably fewer than in patients taking sulphadimidine.Keywords
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