Effects of Bilateral Vagotomy on Renal Function in the Rat

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Abstract
Renal function was studied in rats before and after section of the vagus nerves at the level of the common carotid arteries. In the control group of rats, sodium output and volume rate of urine flow increased following vagal section but glomerular filtration rate did not change. This response was not altered in other rats by desoxycorticosterone acetate, vasopressin, or renal nerve section. This response was similar to that seen in rats in which both common carotid arteries had been occluded. The natriuresis following bilateral vagotomy did not occur in rats in which the blood pressure was prevented from rising by means of aortic constriction. It is concluded that a natriuresis does occur following bilateral vagotomy. This natriuresis may be a result of the effect of arterial blood pressure following the vagotomy.

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