Myxoid leiomyosarcoma of the uterus

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Abstract
Six myxoid leiomyosarcomas of the uterus are described. Four were located within the myometrium and 2 lay predominantly within the broad ligament but appeared to have arisen in the outer myometrium. These tumors were characterized grossly by a gelatinous appearance and an apparently circumscribed border. On microscopical examination, they were observed to invade adjacent tissue and in 2 cases the lumens of veins. All the tumors contained copious amounts of myxomatous stroma. Although it was difficult to establish the nature of the neoplastic cells in some areas of these tumors, both light microscopical and EM examination showed characteristic features of smooth muscle cells in other areas. The mitotic count varied from 0-2/10 high-power fields. Follow-up investigation for periods ranging from 1-11 yr revealed that 4 patients died and 2 are living with disease.