Induction of Tolerance to Skin Homografts by Administering Splenic Cells to Pyridoxine-Deficient Mice.
- 1 May 1964
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 116 (1) , 206-210
- https://doi.org/10.3181/00379727-116-29202
Abstract
Summary 1. Tolerance of CBA/J mice to skin grafts from C3H/HeJ mice has been achieved by injection of C3H/HeJ splenic cells into pyridoxine-deficient CBA/J recipients. Skin grafting was performed subsequent to pyridoxine therapy. 2. Splenic cells obtained from A/HeJ cells were ineffective under otherwise identical conditions. 3. Grafts of tolerant CBA/J mice were rejected following injection with syngeneic cells sensitized to C3H/HeJ skin.Keywords
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