EFFECT OF ANDROGENS AND ANABOLIC STEROIDS ON THE PLASMA DISAPPEARANCE CURVE AND THE DISTRIBUTION OF [1,2-3H CORTICOSTERONE IN THE RAT

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Abstract
Adult male rats were treated with daily doses (per 100 g of body weight) of 1 mg testosterone propionate (TP), 1 mg 19-nortestosterone phenylpropionate (NTPP), 2 mg methyltestosterone, 2 mg methandrostenolone, or 2 mg stanozolol for 7 consecutive days. Other groups of rats were either castrated or castrated and treated with TP. No differences could be detected between the control and experimental groups with regard to plasma levels of endogenous corticosterone 24 hours after the last doses had been administered. All experimental approaches enhanced the plasma half-life of [1,2-3H] corticosterone. The distribution volume of labelled corticosterone decreased after parenteral TP and NTPP, but increased after oral methandrostenolone and stanozolol. Castration increased the distribution volume but administration of TP to castrated animals normalized this value. Administration of NTPP, methandrostenolone or TP to intact rats for 7 days did not influence the adrenal weight, adrenal corticosterone content, corticosterone level in the adrenal vein plasma, corticosterone secretion rate or the adrenal blood flow.

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