The Synthesis of the New 1,4,2-Dithiazine Ring
- 1 February 1972
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 45 (2) , 525-528
- https://doi.org/10.1246/bcsj.45.525
Abstract
Some derivatives of N-(2-phenylethene-l-sulfonyl)-N′-alkylthioureas of the R1C6H4CH=CHSO2NHCSNHR2 2 type were synthesized by a reaction between 2-phenylethene-l-sulfonamides 1 and isothiocyanates in acetone in the presence of K2CO3. A new heterocyclic system, 3-alkylamino-5-phenyl-1,1-dioxo-5,6-dihydro-l,4,2-dithiazine 3, was obtained by the intramolecular Michael cycloaddition of 2 in weakly basic media, and also by the thermal cyclization of 2. The carbon-sulfur bond in 3 could be cleaved to give 2 again in strongly basic media.Keywords
This publication has 1 reference indexed in Scilit:
- Über einige Derivate der β‐StyrolsulfonsäureJournal für Praktische Chemie, 1966