SOME ASPECTS OF THE METABOLISM OF COENZYME Q IN THE RAT

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Abstract
Administration of [C14]coenzyme Q10 by oral or intra-cardial routes to rats resulted in its exclusive incorporation into liver. Although this radioactivity rapidly decreased, it was not transferred to other tissues even after 48 hours. The greater part of the radioactivity in the unsaponifiable lipids of liver was in the form of unchanged coenzyme Q10, even after 24 hours. Under these conditions, administered [C14]coenzyme Q10 was not converted into its cyclic isomer, ubi-chromenol. The coenzyme Q content of rat fetuses increased during development. Blood coenzyme Q can pass through placenta and become incorporated into the fetuses. Injected[C14]coenzyme Q10 is rapidly removed from rat blood. Dietary coenzyme Q seems to be the source of blood coenzyme Q and therefore assumes indirect importance in embryonic development. Several rat tissues are capable of synthesizing [C14]coenzyme Q from [2-C14]mevalonic acid.

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