Axonal Transport of Dopamine-β-Hydroxylase by Human Sural Nerves in vitro
- 22 June 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 180 (4092) , 1295-1297
- https://doi.org/10.1126/science.180.4092.1295
Abstract
Dopamine-beta-hydroxylase activity accumulated above a ligature on biopsy samples of normal human sural nerves incubated in vitro. The rate of accumulation indicated that this enzyme was transported distally at a velocity of 2 millimeters per hour. Axoplasmic transport of dopamine-beta-hydroxylase was greatly reduced in sural nerves from a few patients with peripheral neuropathies.Keywords
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