PHYSIOLOGICAL EFFECTS OF HETEROZYGOUS RECESSIVE MUTANTS INDROSOPHILA MELANOGASTER

Publisher Website
Google Scholar
Abstract
Uptake into blood and incorporation into tissue protein of cystine-S35 and leucine-1-C14 was studied in larvae heterozygous for lightoid (ltd) or claret (ca). Lightoid heterozygotes showed significantly higher levels in the blood for both amino acids. In tissue proteins the specific activity of leucine was the same in both genotypes. Incorporation of cystine into protein was significantly greater in ltd than in ca heterozygotes. Oxidative phosphorylation was studied in mitochondria isolated from 72-hr. larvae of the genotypes +/+ , +/ltd and +/ca- Oxygen uptake was similar in all 3 genotypes but values for phosphorylation in ltd heterozygotes were significantly lower than those found for wild type homozygotes or ca heterozygotes. Heterozygotes with similar morphological phenotypes may possess different physiological phenotypes.