Prostaglandin inhibition of amphetamine-induced circling in mice

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Abstract
The effect of prostaglandins (PG) on amphetamine(AMPH)-induced circling was examined in mice unilaterally lesioned with 6-hydroxy-dopamine. At doses of 0.03–1.0 nmol/g, intraventricularly injected PGD2, PGE2, and PGF2α all inhibited AMP-induced circling, while thromboxane-B2 (TxB2) was inactive at 1.0 nmol/g. The inhibition of circling was not due to alterations in body temperature as measured by rectal temperature changes. When injected intrastriatally, the same major PG inhibited AMP-induced circling at the lower doses of 0.01–0.1 nmol/g, while the PGE2 metabolite 13,14-dihydro-15-keto-PGE2 was inactive at 0.1 nmol/g. PG administered alone did not procude circling. For both routes of administration, the order of potency was PGE2>PGD2>PGF2α. These results suggest that PG can alter motor function governed by central dopaminergic pathways.