Evidence of Lower Toxicity During Thyroxine Suppression After a Single 3-mgl-Thyroxine Dose: Comparison to the Classicall-Triiodothyronine Test for Thyroid Suppressibility
- 1 May 1974
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 38 (5) , 902-905
- https://doi.org/10.1210/jcem-38-5-902
Abstract
Thyroidal suppressibility after oral administration of a single dose of 3 mg l-T4 and after multiple daily doses of l-T3 proved to be equivalent. There were no clinical disturbances during the l-T4 suppression test. Radioimmunoassay of T3 and T4 showed extreme elevations of serum T3 up to 10.05 ng/ml during the classical T3 suppression test, while in the l-T4 test initial serum T4 peaks of 220–390 ng/ml were correlated with only minor serum T3 elevations of about 1.00 ng/ml above baseline levels. It seems evident that this practicable T4 suppression test is less hazardous than the usual T3 suppression test.Keywords
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