Stereochemistry of Decarboxylation Reactions Catalyzed by a Constitutive Aromaticl-Amino Acid Decarboxylase
- 1 November 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 45 (11) , 2553-2557
- https://doi.org/10.1080/00021369.1981.10864918
Abstract
The stereochemistry of the decarboxylation reaction catalyzed by an aromatic l-amino acid decarboxylase, purified from Micrococcus percitreus, was studied using stereospecifically deuterium labelled phenylalanine (Phe). The 1H NMR spectrum of [1,2-2H2]-β-phenethylamine enzymatically derived from (2S, 3R)-[3-2H]-Phe in 2H2O was compared with that of [1-2H]-β-phenethylamine from unlabelled Phe in 2H2O. The results clearly indicate that the decarboxylation reaction of this enzyme proceeds exclusively through a course in which the configuration at C-2 of Phe is retained.This publication has 1 reference indexed in Scilit:
- Distribution and Formation of Aromaticl-Amino Acid Decarboxylase in BacteriaAgricultural and Biological Chemistry, 1977