CHANGES IN PROPORTION OF GUINEA-PIG GAMMA1 AND GAMMA2 ANTIBODIES DURING IMMUNIZATION AND CELLULAR LOCALIZATION OF THESE IMMUNOGLOBULINS

  • 1 January 1968
    • journal article
    • research article
    • Vol. 14  (5) , 601-+
Abstract
Guinea-pigs immunized with DNP-BSA [dinitrophenyl-bovine serum albumin] first produced anti-DNP antibodies of the gamma2-class followed by anti-DNP antibodies of the gamma1-class. The cellular localization of gamma2 and gamma1 immunoglobulins was investigated by immunofluorescence techniques during this shifting period. The gamma 2- and gamma 1-classes of immunoglobulins were, with few possible exceptions, produced in separate cells.