Ventricular fibrillation threshold and vulnerable period in the isolated perfused rat heart
- 1 September 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 9 (5) , 613-620
- https://doi.org/10.1093/cvr/9.5.613
Abstract
Ventricular fibrillation threshold (VFT) measurements were obtained in the isolated perfused rat heart. Detailed morphology of the vulnerable period (VP) could be described by stimulating repeatedly at increasing levels of stimulus energy. Addition of lignocaine to the system caused an elevation of VFT, but also led to a delay of the VP to the end of the QT interval. The implications of these findings for the understanding of VFT measurements are discussed.Keywords
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