MRI quantitative myocardial perfusion with compartmental analysis: A rest and stress study

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Abstract
K1 (first‐order transfer constant from arterial plasma to myocardium for Gd‐DTPA) and Vd (distribution volume of Gd‐DTPA in myocardium) were measured in vivo in a canine model (n = 5) using MRI‐derived myocardial perfusion curves and a compartmental model. Perfusion curves were obtained after a bolus injection of Gd‐DTPA (0.04 mM/kg) with an inversion‐prepared fast gradient echo sequence. Myocardium and blood signal intensity were converted to a concentration of Gd‐DTPA, according to a model appropriate for short (1 and Vd, obtained from the fit of the MRI‐derived perfusion curves, were 6.2 ± 1.4 (mHz) and 17.5 ± 4.2%, respectively. After dipyridamole infusion, a K1 increase of a factor of 2.82 ± 0.72 was measured (P = 0.003). No change was observed in Vd (P = 0.98). These results suggest that the K1 increase after dipyridamole reflects a flow‐related effect that can be useful to quantity the MRI‐derived perfusion curves.

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