Competitive binding of the anticancer drug titanocene dichloride to N,N ′-ethylenebis(o-hydroxyphenylglycine) and adenosine triphosphate: a model for TiIV uptake and release by transferrin

1 January 2000

journal article
Published by Royal Society of Chemistry (RSC) in J. Chem. Soc., Dalton Trans.

No. 1,p. 7-9
https://doi.org/10.1039/a908759a

Abstract

¹H and ³¹P NMR studies show that in aqueous solution the anticancer agent titanocene dichloride (Cp₂TiCl₂) binds selectively to N,N′-ethylenebis(o-hydroxyphenylglycine) (H₄ehpg) at neutral pH, but preferentially to adenosine triphosphate (ATP) at pH* values below 5.1; intermolecular Ti^IV transfer from [Ti^IV(ehpg)(H₂O)] to ATP occurs at acidic pH values.

Keywords

ANTICANCER
TITANOCENE DICHLORIDE
MODEL
ETHYLENEBIS
HYDROXYPHENYLGLYCINE
UPTAKE

This publication has 0 references indexed in Scilit: