Changes in plasma volume, in transcapillary escape rate of albumin and in subcutaneous blood flow during hypoglycaemia in man

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Abstract
Hypoglycemia was induced by insulin injected i.v. (0.15 i.u./kg body wt) in 7 healthy young males. Plasma volume was measured before and during hypoglycemia by i.v. injection of 125I before hypoglycemia and of 131I during hypoglycemia. Plasma volume decreased and transcapillary escape rate increased significantly during hypoglycemia. Skin temperature and local s.c. adipose tissue blood flow were measured in 4 different regions. Both tended to decrease during hypoglycemia and decreased significantly 2 h after hypoglycemia. There was no correlation between changes in the 2 measurements suggesting that there is no simple relationship between s.c. blood flow and skin temperature during hypoglycemia.