In vivo measurement of [11C]verapamil kinetics in human tissues

1 January 2001

journal article
clinical trial
Published by Springer Nature in European Journal of Clinical Pharmacology

Vol. 56 (11) , 827-829
https://doi.org/10.1007/s002280000253

Abstract

Objective: To evaluate [¹¹C]verapamil kinetics in humans. Methods: After intravenous injection of [¹¹C]verapamil (370 MBq, specific activity >1600 GBq/mmol), kinetics were evaluated in five cancer patients using positron emission tomography (PET). Results: One hour after injection, accumulation of [¹¹C] in lungs, heart and tumour was 43.0%, 1.3% and 0.9% of the injected verapamil dose, respectively. Half-lives of [¹¹C]verapamil in these tissues were 46.2 min, 73.8 min and 23.7 min, respectively. Conclusions: Intravenously administered [¹¹C] was mainly extracted by the lungs. Transport of a [¹¹C]verapamil bolus out of solid tumour tissue is relatively fast.

Keywords

[11C]VERAPAMIL KINETICS LUNG EXTRACTION POSITRON EMISSION TOMOGRAPHY

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