Cutaneous Lymphoplasia With Giant Follicles

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Abstract
Out of 115 patients with typical cutaneous lymphoplasia eight (six female, two male) are described in case reports. In these eight cases the histologic variability of the follicular germinal center in cutaneous lymphoplasia had gone to an extreme: numerous large reticulum cells surrounded by a narrow rim of densely packed lymphocytes were arranged into giant follicles. Many of these large reticulum cells contained round polychrome bodies which are considered a reliable diagnostic criterion for the diagnosis of cutaneous lymphoplasia. Such polychrome bodies correspond to the Flemming bodies in mature lymphadenoid tissue. Fissures were frequently observed in the giant follicles upon histology. The presence of such fissures may lead to confusion with follicular lymphoma (Brill-Symmers disease) and, therefore, is not a reliable diagnostic criterion for either condition. The clinical and histologic differentiation of cutaneous lymphoplasia with giant follicles has been outlined in detail.

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