THE SELECTIVE OCCURRENCE OF γ1A GLOBULINS IN CERTAIN BODY FLUIDS*

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Abstract
Normal parotid saliva contains large amounts of gamma-globulin relative to other serum proteins and has a gamma-globulin albumin ratio approximately 6 times greater than that of serum. Most of the gamma-globulin in parotid saliva is closely related to, if not identical with, serum gamma1A. Human colostrum and normal urine were found to contain significant amounts of gamma1A immunologically identical with the gamma-globulin in parotid saliva. The gamma1A in colostrum, saliva, and urine have sedimentation rates in the 7-11S range as demonstrated by density gradient and immunological analysis. The results of immunological studies suggest that secretion is highly selective, although the possibility of local synthesis cannot be excluded, it is suggested that gamma1A contains a specific (transport) site that is responsible for its secretion into these biological fluids.