Prenatal identification of small mosaic markers of different chromosomal origins
- 1 February 1992
- journal article
- case report
- Published by Wiley in Prenatal Diagnosis
- Vol. 12 (2) , 83-91
- https://doi.org/10.1002/pd.1970120203
Abstract
In situ hybridization using a series of alphoid DNA probes has demonstrated the origin of two small accessory mosaic marker chromosomes ascertained from 1079 amniocenteses. These markers appeared to be de novo, derived from acrocentric chromosomes, and identical by traditional cytogenetic staining (G, Q, C, AgNOR, Hoechst‐distamycin). Molecular characterization showed that one marker had originated from chromosome 14, the other from chromosome 22. Clinical outcome in both cases was normal.Keywords
This publication has 21 references indexed in Scilit:
- Correlation between phenotypic expression ofde novo marker chromosomes and genomic organization using replicational bandingPrenatal Diagnosis, 1990
- Small marker chromosomes in man: origin from pericentric heterochromatin of chromosomes 1, 9, and 16.Journal of Medical Genetics, 1990
- A subfamily of alphoid repetitive DNA shared by the nor-bearing human chromosomes 14 and 22Genomics, 1988
- Two subsets of human alphoid repetitive DNA show distinct preferential localization in the pericentric regions of chromosomes 13, 18, and 21Cytogenetic and Genome Research, 1986
- Forty four probands with an additional ?marker? chromosomeHuman Genetics, 1985
- Organization of a repetitive human 1.8 kb KpnI sequence localized in the heterochromatin of chromosome 15Chromosoma, 1985
- A simple method of reducing the fading of immunofluorescence during microscopyJournal of Immunological Methods, 1981
- DNA synthesis in a multi-enzyme system from Xenopus laevis eggsCell, 1978
- Visualization of nucleolar organizer regions in mammalian chromosomes using silver stainingChromosoma, 1975
- The 24 fluorescence patterns of the human metaphase chromosomes - distinguishing characters and variabilityHereditas, 1971