Relationship of Shigella Alkalescens to Other Members of the Shigella Group

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Abstract
Shigella alkalescens (B. alkalescens of Andrewes) was isolated from several cases and 1 food handler (not ill) in an outbreak of dysentery in which other significant organisms could not be isolated; sera from the patients agglutinated it. After relieving the food handler from duties, no further cases developed. It was also isolated from catheterized urine in 4 unrelated cases with clinical diagnosis of nephritis and no intestinal symptoms. By agglutination, agglutinin absorption and the Shwartzman reaction a distinct relationship to other members of the dysentery group was demonstrated, and furthermore, Shiga anti-filtrate horse serum neutralized the toxic effect of S. alkalescens filtrates in rabbits and mice. It is suggested that S. alkalescens may be at times capable of causing disease in man.

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