The Effect of Psychotropic Drugs on the TSH-Response to Thyroliberin (TRH)
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in Neuroendocrinology
- Vol. 24 (2) , 90-97
- https://doi.org/10.1159/000122700
Abstract
The effect of chlorpromazine (CPZ), thioridazine (TR), L-dopa, fusaric acid (FA), pimozide (PZ) and propranolol (P) on the i.v. thyrotropin-releasing hormone (TRH) stimulation test was studied in 75 subjects. It was found that chronic treatment with CPZ, TR and L-dopa inhibits the response to TRH. FA may to some extent counteract the effect of L-dopa. The results indicate that the response of the pituitary to TRH as regards the secretion of TSH is mainly regulated by norepinephrinergic α-receptors.Keywords
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