Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis.
Open Access
- 1 September 1991
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 174 (3) , 593-601
- https://doi.org/10.1084/jem.174.3.593
Abstract
18 cloned T cell lines reactive with Borrelia burgdorferi proteins, all CD3+4+8-TCR-alpha/beta+ and restricted by HLA class II proteins, were isolated from four patients with chronic Lyme arthritis. Analysis of these T cell clones indicated that the T cell response to the Lyme disease spirochete is not oligoclonally restricted; yet all produced the same pattern of lymphokines, resembling that of murine type 1 T helper cells, after antigen-specific or nonspecific stimulation. Therefore, a subset of human CD4+ T cells, with a distinct profile of lymphokine secretion, is selectively activated by the pathogen inciting this chronic inflammatory disease.Keywords
This publication has 34 references indexed in Scilit:
- A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis.The Journal of Experimental Medicine, 1991
- Lyme Borreliosis in Selected Strains and Ages of Laboratory MiceThe Journal of Infectious Diseases, 1990
- Shared Human T Cell Receptor V β Usage to Immunodominant Regions of Myelin Basic ProteinScience, 1990
- Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patientsNature, 1990
- The V-region disease hypothesis: evidence from autoimmune encephalomyelitisImmunology Today, 1989
- The Biology of Cachectin/TNF -- A Primary Mediator of the Host ResponseAnnual Review of Immunology, 1989
- Epitope mapping of recombinant human gamma interferon using monoclonal antibodiesMolecular Immunology, 1989
- Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapyCell, 1988
- Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune interventionCell, 1988
- HUMAN CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX GENES AND PROTEINSAnnual Review of Biochemistry, 1988