Methotrexate nephrotoxicity.

  • 1 January 1979
    • journal article
    • Vol. 5, 43-5
Abstract
The use of high dose methotrexate therapy in the treatment of malignant disease has been complicated by nephrotoxicity. Analysis of the basic physico-chemical properties of methotrexate has allowed the development of improved techniques of administering methotrexate, at high dose, which greatly reduces the incidence of nephrotoxicity.

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