DNA vaccines coding for heat-shock proteins (HSPs): tools for the activation of HSP-specific regulatory T cells
- 22 April 2005
- journal article
- review article
- Published by Informa Healthcare in Expert Opinion on Biological Therapy
- Vol. 5 (4) , 545-554
- https://doi.org/10.1517/14712598.5.4.545
Abstract
Heat-shock proteins (HSPs) perform opposing functions in autoimmune arthritis. HSP-specific T cells drive the progression of adjuvant arthritis (AA), an experimental model of autoimmune arthritis. However, HSP-specific T cells can also have a regulatory phenotype, controlling arthritogenic T cells and inhibiting AA progression. This manuscript reviews the use of DNA vaccines coding for HSPs to analyse the role of these proteins in the regulation of arthritis. Recent studies suggest that HSPs participate in the control of pathological autoimmunity. Indeed, DNA vaccines coding for HSPs can be used to activate these HSP-specific built-in regulatory mechanisms. Thus, DNA vaccines coding for HSPs may serve not only as tools for the dissection of immunoregulatory mechanisms, but also as agents for the treatment of autoimmune disorders.Keywords
This publication has 76 references indexed in Scilit:
- Inhibition of adjuvant‐induced arthritis by DNA vaccination with the 70‐kd or the 90‐kd human heat‐shock protein: Immune cross‐regulation with the 60‐kd heat‐shock proteinArthritis & Rheumatism, 2004
- The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat‐shock protein 60 capable of producing the regulatory cytokine interleukin‐10Arthritis & Rheumatism, 2003
- Relationship between disease severity and responses by blood mononuclear cells from patients with rheumatoid arthritis to human heat‐shock protein 60Immunology, 2000
- Autoreactivity to human heat‐shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritisArthritis & Rheumatism, 1996
- Suppression of adjuvant arthritis in rats by induction of oral tolerance to mycobacterial 65-kDa heat shock proteinEuropean Journal of Immunology, 1996
- A 71-kD heat shock protein (hsp) from Mycobacterium tuberculosis has modulatory effects on experimental rat arthritisClinical and Experimental Immunology, 1996
- Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favorable course of arthritis.Journal of Clinical Investigation, 1995
- Stress proteins, arthritis, and autoimmunityArthritis & Rheumatism, 1989
- Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans.Proceedings of the National Academy of Sciences, 1985
- Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II.Journal of Clinical Investigation, 1984